This paper, based on the development strategy of Yangtze River economic zone, studies its coupling coordination between urbanization and water resources from 2006 to 2015 from temporal and spatial perspectives by setting up a comprehensive evaluation index system via entropy method and a coupling coordination model updated by TOPSIS. The result shows an escalating urbanization development and water resources use level, and thus a rising coupling coordination. The coordination degree has an outstanding locality concentration in the eleven provinces along the Yangtze River, high in the east and low in the central. This paper presents suggestions on boosting urbanization development in the western regions, increasing water resources comprehensive use and driving coordinated development of economy and eco-environmental protection in Yangtze River economic zone.